CHEM305 - Biological Chemistry
CHEM 305 Biological Chemistry is an 18-point paper available in the first semester.
This course focuses on how the concepts and techniques from various fields of chemistry may be applied to interpret chemical transformations in biological systems and to determine the structure of biomolecules. The paper will evaluate frontiers in biological chemistry by identifying the underlying fundamental concepts of molecular transformation and structure. It is a course for chemistry majors wishing to proceed to a career that involves biological chemistry and also for all general degree students requiring knowledge and understanding of biological chemistry.
Lecture Course: 32 lectures
Amino Acids and Peptides
- The chemistry and reactivity of amino acids and peptides. Methods of isolation, purification and analysis of peptides and proteins. Strategies used in the chemical synthesis of peptides.
- The role and modes of action of enzymes in catalysing biological reactions. Structure activity relationships and kinetics of enzymes. Mechanisms of enzyme reactions using proteases as examples. Strategies for enzyme inhibition in drug design.
Spectroscopy of Biological Systems
- Spectroscopic investigations are integral to the study of biological systems. The principles and applications of NMR, EPR and Mössbauer spectroscopy to study metalloenzymes.
- An overview of polymers and their properties. Chemical synthesis of natural polymers. Biocompatible and biodegradable polymers. Use of polymers in drug delivery and devices.
Semester 1 Tuesday, Thursday and Friday at 9:00 am
Laboratory Course: 11 days scheduled
There will be four laboratory assignments. The first assignment takes one day; subsequent experiments involve two-day laboratories. Laboratory assignments will be assessed on the basis of a written report and laboratory performance.
Laboratory time and venue
Semester 1 Monday or Wednesday at 2.00 pm (Chemistry Labs, second floor, Science I)
Expectations at the completion of the course
- An understanding of the scientific concepts underlying chemical transformation and structure determination involving biological molecules
- An appreciation of the chemical factors controlling biological processes
- An ability to identify fundamental concepts in chemistry underlying biological systems
- Tested experience with the generic activities of information retrieval, critical analysis and presentation, logistical planning and cooperative teamwork
- An understanding of how chemical knowledge is applied in a practical, problem-solving context
Final two hour examination 60%
Laboratory and project assessment 40%
Jones, J. Amino acid and peptide synthesis, Oxford University Press
Bruice, P.Y. Organic Chemistry, (4th edn), Prentice-Hall
Fersht, A. Enzyme structure and mechanism, Freeman
Dr. Alan R. Hayman
Dr. Guy N. L. Jameson
Assoc. Prof. Steve Moratti